Agents that increase cellular cyclic AMP inhibit proliferative activity and decrease lipid content in cells cultured from atherosclerotic human aorta.

V V Tertov; A N Orekhov; V N Smirnov

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PubMed · 2430551

Agents that increase cellular cyclic AMP inhibit proliferative activity and decrease lipid content in cells cultured from atherosclerotic human aorta.

V V Tertov·A N Orekhov·V N Smirnov

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Abstract

Cholera toxin, methylisobutylxanthine and prostacyclin (PGI2) analogues as well as dibutyryl cyclic AMP inhibit by 2-7-fold 3H-thymidine uptake into intimal cells isolated from atherosclerotic human aorta in primary culture. These agents also decrease cholesteryl ester and triglyceride levels and do not affect content of phospholipids and free cholesterol in cells cultured from atherosclerotic lesions.

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1-Methyl-3-isobutylxanthine Aorta Arteriosclerosis Bucladesine Cell Division Cholera Toxin Cyclic AMP Epoprostenol Humans In Vitro Techniques Lipids Theophylline Thymidine Journal Article

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V V Tertov, A N Orekhov, V N Smirnov. 1986. Agents that increase cellular cyclic AMP inhibit proliferative activity and decrease lipid content in cells cultured from atherosclerotic human aorta.. https://pubmed.ncbi.nlm.nih.gov/2430551/

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