Baroreceptor mechanisms at the cellular level.

F Sachs

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PubMed · 2433161

Baroreceptor mechanisms at the cellular level.

F Sachs

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Abstract

Nothing is known of transduction mechanisms of baroreceptors in vivo. Not even the site of transduction is known. However, there are mechanotransducer ion channels that provide a useful model system of transduction. In these channels, transduction is accomplished by a strain-dependent increase in the probability of being open. Membrane tension is coupled to the channel by cytoskeletal strands that concentrate the strain energy from a large (approximately equal to 4000 A diameter) area of membrane and thereby provide high sensitivity. The channel is fast and does not inactivate, but viscoelastic coupling to the channel can dramatically alter the transfer function.

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Animals Biomechanical Phenomena Cell Membrane Cytoskeleton Elasticity Ion Channels Kinetics Mechanoreceptors Models, Neurological Pressoreceptors Rats Stress, Mechanical Viscosity Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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F Sachs. 1987. Baroreceptor mechanisms at the cellular level.. https://pubmed.ncbi.nlm.nih.gov/2433161/

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