Decrease of atrial natriuretic peptide content in rat superior cervical sympathetic ganglion after denervation and axotomy.

Y Nagata; H Ebisu; M Tamaru; K Fujita; T Koide

doi:10.1111/j.1471-4159.1989.tb09210.x

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Decrease of atrial natriuretic peptide content in rat superior cervical sympathetic ganglion after denervation and axotomy.

Y Nagata·H Ebisu·M Tamaru·K Fujita·T Koide

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Abstract

We found atrial natriuretic peptide (ANP), known as a humoral factor in regulating body fluid volume and blood pressure, in considerable quantities in rat superior cervical sympathetic ganglion (SCG) by radioimmunoassay after separation with reverse-phase HPLC. Although the ANP content of the immature rat 1 week after birth was low, it doubled at 2 weeks and then increased gradually, until it reached the adult level. Denervation caused a rapid decrease in the ANP content to half of the intact SCG level after 3 h, which then fell to 10% of the control value on day 2 after operation. The time course of ANP content reduction after denervation was similar but rather faster than that of activity of the acetylcholine-synthesizing enzyme, choline acetyltransferase, an observation suggesting that ANP may partly contribute to cholinergic synaptic transmission. On the other hand, axotomy produced a rather slower decrease in the ANP content than did denervation. Enucleation and sialoadenectomy also caused a considerable reduction of the ANP content. Thus, part of the ANP found in the ganglion is apparently transported from sympathetically innervated extraganglionic organs via retrograde axoplasmic flow.

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Aging Animals Atrial Natriuretic Factor Axonal Transport Axons Brain Choline O-Acetyltransferase Chromatography, High Pressure Liquid Denervation Eye Female Ganglia, Sympathetic Kinetics Male Rats Rats, Inbred Strains Salivary Glands Comparative Study Journal Article

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Y Nagata, H Ebisu, M Tamaru, K Fujita, T Koide. 1989. Decrease of atrial natriuretic peptide content in rat superior cervical sympathetic ganglion after denervation and axotomy.. https://doi.org/10.1111/j.1471-4159.1989.tb09210.x

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