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PubMed · 2476120

Protein stabilization by blocking the native unfolding nucleus.

A Schellenberger·R Ulbrich
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Abstract

Studies on the thermal inactivation of immobilized enzymes result in a novel conception of protein stabilization. The native protein molecule is suggested to be characterized by a specific structural region where the unfolding process starts. Accordingly, enzyme stabilization by immobilization is the result of blocking this unfolding nucleus.

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AmylasesChymotrypsinEnzyme StabilityEnzymes, ImmobilizedHot TemperatureProtein DenaturationThermodynamicsTrypsinJournal Article

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A Schellenberger, R Ulbrich. 1989. Protein stabilization by blocking the native unfolding nucleus.. https://pubmed.ncbi.nlm.nih.gov/2476120/

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