Immunoglobulin lambda-light-chain-derived amyloidosis (A lambda) in two horses.

R P Linke; G Trautwein

doi:10.1007/bf00320431

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Immunoglobulin lambda-light-chain-derived amyloidosis (A lambda) in two horses.

R P Linke·G Trautwein

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Abstract

Tumorous amyloid deposits in the nasal mucosa of two horses differed from generalized AA-amyloidosis with respect to clinical features, organ distribution, and resistance to KMnO4 treatment. Using a panel of antibodies directed against different human amyloid fibril proteins and employing the peroxidase-anti-peroxidase (PAP) technique, we showed the described equine amyloid to be A lambda-type, as demonstrated by immunohistochemical cross-reactivity. Consequently, we identified a second amyloid class in horses and showed that immunoglobulin light-chain-derived amyloid may also be present in animals.

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Amyloid Amyloidosis Animals Cross Reactions Female Horse Diseases Horses Humans Immunoglobulin lambda-Chains Immunohistochemistry Male Nasal Mucosa Nose Neoplasms Case Reports Journal Article Research Support, Non-U.S. Gov't

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R P Linke, G Trautwein. 1989. Immunoglobulin lambda-light-chain-derived amyloidosis (A lambda) in two horses.. https://doi.org/10.1007/bf00320431

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