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Eicosanoids in renal function.

C J Lote·J Haylor
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Abstract

The major role of renal eicosanoid synthesis appears to be a protective one. In the cortex, prostaglandin synthesis minimises potential anoxic and ischaemic damage by vasodilatation. In the medulla, prostaglandin synthesis appears to stabilise the corticomedullary solute gradient and may play a role in cell volume regulation. Mono-oxygenase production at this site, by modifying blood flow and cellular active transport processes could again serve a protective function against anoxia and ischaemia. The release of erythropoietin also appears to be prostaglandin dependent. It is likely that leukotrienes released from inflammatory cells within the kidney will affect renal haemodynamics and capillary permeability as in other tissues.

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AnimalsArachidonic AcidArachidonic AcidsHumansKidneyLipoxygenaseProstaglandin-Endoperoxide SynthasesProstaglandinsVasopressinsJournal ArticleReview

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C J Lote, J Haylor. 1989. Eicosanoids in renal function.. https://doi.org/10.1016/0952-3278(89)90134-8

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