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PubMed · 2540743

Altered hepatic microsomal function and elevated protooncogene expression as residual effects in rats exposed to delta-9-tetrahydrocannabinol.

H R Prasanna·K D Nakamura·S F Ali·M H Lu·W Slikker·R W Hart
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Abstract

The microsomal activation of the potent hepatocarcinogen aflatoxin B1 (AFB1) and the expression of selected protooncogenes were investigated in the livers of rats exposed to delta 9-tetrahydrocannabinol (THC). At equimolar levels of cytochrome P-450, the microsome-mediated binding of AFB1 to DNA was significantly lower (56% of the controls) in preparations from drug exposed rats. Hepatic expression of the c-k-ras protooncogene was 3-fold higher in THC exposed animals. These results suggest the possible occurrence of long lasting residual effects in the rats exposed to THC.

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Aflatoxin B1AflatoxinsAnimalsCytochrome P-450 Enzyme SystemDNADronabinolGene Expression RegulationGlutathione TransferaseLiverMaleMicrosomes, LiverOrgan SizeProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Proto-OncogenesRatsRats, Inbred StrainsJournal Article

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H R Prasanna, K D Nakamura, S F Ali, M H Lu, W Slikker, R W Hart. 1989-04-14. Altered hepatic microsomal function and elevated protooncogene expression as residual effects in rats exposed to delta-9-tetrahydrocannabinol.. https://doi.org/10.1016/0006-291x(89)91643-4

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