Insertional mutations in transgenic mice.

F Costantini; G Radice; J L Lee; K K Chada; W Perry; H J Son

doi:10.1016/s0079-6603(08)60169-5

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Insertional mutations in transgenic mice.

F Costantini·G Radice·J L Lee·K K Chada·W Perry·H J Son

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Abstract

Insertional mutagenesis represents a promising approach to the identification of new genes involved in mammalian development. In this paper, we have presented a brief review of the literature on the analysis of mutations caused by DNA and retroviral insertion into the mouse genome. We have discussed several methods that we and others have used to identify recessive insertional mutations among transgenic mouse lines. Finally, we have summarized the results of our studies to date on three recessive prenatal lethal mutations that we have identified.

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Animals DNA Transposable Elements Genes, Lethal Genes, Recessive Homozygote Mice Mice, Transgenic Mutation Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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F Costantini, G Radice, J L Lee, K K Chada, W Perry, H J Son. 1989. Insertional mutations in transgenic mice.. https://doi.org/10.1016/s0079-6603(08)60169-5

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