PubMed · 2546897
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B C Walton. 1989. Leishmaniasis. A worldwide problem.. https://doi.org/10.1111/j.1365-4362.1989.tb01349.x
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Visceral leishmaniasis is a parasitic disease endemic in the Mediterranean Basin, including Malta. Finnish-type congenital nephrotic syndrome is an autosomal recessive condition that presents in the first 3 months of life with heavy proteinuria, hypoalbuminemia with secondary edema, and hyperlipidemia. We present an infant with congenital nephrotic syndrome who had had unilateral nephrectomy and who also developed visceral leishmaniasis. He was successfully cleared of the infection by the administration of sodium stibogluconate, with no deterioration of renal function or other complications.
The incidence of leishmaniasis is increasing globally due to population and environmental changes. Ease of worldwide travel and immigrant populations means that the UK surgeon is more likely to encounter cutaneous lesions. Two cases are presented and treatment options discussed.
Forty-two CL patients with 60 lesions were treated with cryotherapy using liquid nitrogen twice for two months. Another group of fifty-five CL patients. With 73 lesions were treated with intralesional pentostam with pentostam, 67 of 73 lesions (92%) and with cryotherapy 47 of 60 lesions (78%) healed or markedly improved at the end of three months follow-up. This study shows that intralesional pentostam injection was effective than cryotherapy. However, both lines of treatment were well tolerated by the patients. They showed no severe side effects and no significant changes in laboratory values. It is suggested that cryotherapy is an alternative to intralesional pentostam injection.