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PubMed · 2578671

Internal antigen and immune network.

H Kohler·S Muller·C Bona
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Abstract

The network hypothesis postulates the existence of internal idiotopic structures which mimic nominal antigens. Experimental evidence for idiotope internal antigen is presented and its implication for the Network hypothesis is discussed. The exploitation of the internal idiotope antigens (or preparation of vaccines) is a realistic possibility.

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AnimalsAntibodiesAntibodies, MonoclonalAntigensEpitopesHumansImmunityImmunoglobulin IdiotypesImmunoglobulin MInsulinMiceMice, Inbred BALB CRabbitsRatsTrypanosomiasis, AfricanTurkeysVaccinesJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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H Kohler, S Muller, C Bona. 1985. Internal antigen and immune network.. https://doi.org/10.3181/00379727-178-41996a

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