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PubMed · 2588402

[Blood collection from cadavers].

H F Brettel
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Abstract

Withdrawals of blood from corpses are mainly for determinations of blood alcohol but also for toxikological analyses and blood-typing. When the legal conditions for the withdrawals of blood were discussed the technique of withdrawal and the problems of evaluation are debated. Thereby alterations of the samples through putrefaction are especially considered.

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Blood Specimen CollectionEthanolExpert TestimonyHumansInsurance, AccidentPostmortem ChangesEnglish AbstractJournal Article

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H F Brettel. 1989-11-01. [Blood collection from cadavers].. https://pubmed.ncbi.nlm.nih.gov/2588402/

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Therapeutic drug monitoring of tacrolimus with the dried blood spot method.

In a preliminary investigation an assay for tacrolimus based on fingerprick sampling and consecutive application as a blood spot on sampling paper has been developed. The dried blood spot was analysed by HPLC-tandem mass spectrometry. The validated range was 1-30 microg/l. Intra- and inter-assay variability for precision and accuracy was <7.5% and 15%, respectively. Tacrolimus concentrations of 24 stable out patients were compared after both blood spot sampling and conventional venous sampling. Method agreement was investigated with the methods of Passing and Bablok and Bland Altman and proved suitable for clinical use. The dried blood spot method for tacrolimus seems promising for patient monitoring.

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