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PubMed · 2632541

Alkaptonuria.

B N Singh·S Mehrotra·B Bhargava·S Agarwal
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Abstract

A case of alkaptonuria with its various sequelae in the form of ochronosis, ochronotic arthropathy, spondylitis and prostatic calculi is reported. The case is of interest as it presented with hepatocellular failure and hepatitis B surface antigenaemia.

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AlkaptonuriaCalcinosisHumansIntervertebral DiscMaleMiddle AgedRadiographyCase ReportsJournal Article

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B N Singh, S Mehrotra, B Bhargava, S Agarwal. 1989. Alkaptonuria.. https://pubmed.ncbi.nlm.nih.gov/2632541/

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PubMed1991

The "whisker sign" as an indicator of ochronosis in skeletal scintigraphy.

A patient with alkaptonuria and ochronotic arthrosis was imaged twice with technetium-99m dicarboxypropane diphosphonate (99mTc-DPD)--once during a bout of arthritic knee pain and once when symptom-free. There was a marked accumulation of radioactivity in the large joints. During the episode of arthritis the knee joints had a higher uptake than when the patient was without symptoms. The intervertebral discs showed a high uptake which extended laterally from the axial vertebral column; the finding gave an impression of whiskers, and this "whisker sign" may be characteristic of ochronosis.

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