Ischemia-reperfusion and cell membrane dysfunction.

M O Perry; G Fantini

PubMed · 2637944

Ischemia-reperfusion and cell membrane dysfunction.

Abstract

One to 3 hours of partial skeletal muscle ischemia-reperfusion in dogs and rats causes cell membrane depolarization. Intracellular levels of adenosine triphosphate remain normal, suggesting that direct membrane injury rather than electrogenic pump failure occurs. Membrane depolarization can be prevented by superoxide dismutase and catalase, or by neutrophil depletion. Oxygen free radicals may be one type of mediator causing membrane damage, and it appears that leukocytes release these toxic species.

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Adenosine Triphosphate Animals Catalase Cell Membrane Dogs Female Free Radicals Ischemia Membrane Potentials Muscles Neutrophils Oxygen Phosphocreatine Rats Rats, Inbred Strains Reperfusion Injury Superoxide Dismutase Journal Article

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M O Perry, G Fantini. Ischemia-reperfusion and cell membrane dysfunction.. https://pubmed.ncbi.nlm.nih.gov/2637944/

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