PubMed · 2639407
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J G Whinery. 1989. Abnormal mandibular posture.. https://pubmed.ncbi.nlm.nih.gov/2639407/
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Plasminogen activator (PA) converts plasminogen to plasmin, and plasmin activates the kinin cascade and latent extracellular matrix metalloproteases. The periodontal ligament serves to anchor the tooth to the alveolus and functions as a cushion between these hard tissues to migrate occlusal force during mastication. We reported previously that repeated mechanical tension force (MTF) as an experimental model of a traumatic occlusion, increased PA activity in human periodontal ligament derived fibroblast (hPLF) cells. In this study, the influence of in vitro cellular aging on MTF-stimulated PA activity in hPLF cells was studied. Aged hPLF cells produced a significantly higher PA activity when compared with those of young hPLF cells in response to MTF in a time- and magnitude-dependent manner. tPA mRNA levels in aged cells were higher than those in young cells, whereas PAI-1 mRNA remained unchanged and uPA mRNA was not detected. Because MTF-stimulated PA activity from hPLF cells was increased by in vitro cellular aging, aging of the periodontal ligament may affect the severity of the inflammation and the degradation of the extracellular matrix of periodontal ligament tissue by producing a large amount of PA in response to excessive force such as a traumatic occlusion.
The loss of one or more teeth is normally treated with conventional fixed or removable partial dentures or with implant supported fixed or removable dentures. This study investigated stresses formed around the implant and the antagonist natural tooth under occlusal force in the substitution of a missing lower first molar with a rigid or resilient IMZ (Intra Mobil Zylinder) implant, using the finite element stress analysis method. The results indicate that a bite force of 143 N resulted in high compressive stresses around the roots of a natural tooth opposing a restoration supported by an IMZ implant with rigid type abutment. It is speculated that these high compressive stresses may contribute to intrusion of the tooth.
Masticatory forces or bite forces applied to the teeth are known to generate a compressive force on the temporomandibular joint (TMJ). This intra-articular force is referred to as TMJ loading. TMJ loading is considered to be controlled to a certain extent by the stomatognathic system, so as not to exceed a certain limit. In order to clarify the control mechanism of the TMJ during biting, the controllability of TMJ loading through coordinated activities of the masticatory muscles has been numerically analyzed using a static two-dimensional jaw model. This model consists of a rigid-body model of the jaws and a spring model of the articular disk, which includes three dominant muscle force vectors representing the masseter, temporalis and lateral pterygoid muscles. The bite force vector is assumed to be applied solely at the first molar. Static equilibrium analyses suggest that coordinated activities of the masseter muscle and anterior portion of the temporalis muscle can minimize TMJ loading and concentrate the stress within the articular disk to the intermediate zone of the disk, and that the activity of the posterior portion of the temporalis muscle has the possibility of reducing TMJ loading.