Distinctions between the two-state and sequential models for cooperative ligand binding.

R E Gibson; S A Levin

doi:10.1073/pnas.74.1.139

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Distinctions between the two-state and sequential models for cooperative ligand binding.

R E Gibson·S A Levin

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Abstract

The two-state and sequential models for positive cooperativity in ligand binding can produce significantly different theoretical binding curves when presented in a Scatchard plot. The conditions that produce the greatest differences have been examined. The theoretical differences have been used to select the two-state model as the best model for describing the binding of acetylcholine to acetylcholine receptors that have been solubilized by Triton X-100 and sodium cholate.

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Acetylcholine Allosteric Site Animals Electric Organ Fishes Kinetics Ligands Models, Biological Receptors, Cholinergic Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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R E Gibson, S A Levin. 1977. Distinctions between the two-state and sequential models for cooperative ligand binding.. https://doi.org/10.1073/pnas.74.1.139

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