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PubMed · 2655145

Correlation of visual function with optic nerve and nerve fiber layer structure in glaucoma.

J Caprioli
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Abstract

Careful clinical correlation of the appearance of the optic nerve and retinal nerve fiber layer with measurements of the visual field is an important aspect of the evaluation of patients with glaucoma. The anatomy of the nerve fiber layer and its retinotopic projections to the optic nerve head form the basis of the spatial relationships between structure and function in glaucoma. Clinical experience with the temporal correlations of structure and function indicates that visible alterations of the optic nerve and surrounding nerve fiber layer may occur before scotomas in the visual field can be detected. Quantitative clinical studies of the optic nerve and visual field support this concept, and provide additional clues regarding the pathogenesis of glaucomatous optic nerve damage.

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GlaucomaGlaucoma, Open-AngleNerve FibersOptic DiskOptic NerveRetinal Ganglion CellsVision ScreeningVisual Field TestsVisual FieldsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

J Caprioli. 1989. Correlation of visual function with optic nerve and nerve fiber layer structure in glaucoma.. https://pubmed.ncbi.nlm.nih.gov/2655145/

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Do scleral flap dimensions influence reliability of intraocular pressure control in experimental trabeculectomy?

AIM: To compare the effect on intraocular pressure (IOP) of large vs small scleral flap size during trabeculectomy using adjustable sutures. METHODS: Trabeculectomy operations were performed on nine donor human eyes connected to a constant flow infusion with real-time IOP monitoring. Large scleral flaps (4 x 4 mm, 16 mm(2), n=12) or small scleral flaps (3 x 2 mm, 6 mm(2), n=9) were constructed over 0.76 mm(2) sclerostomies. For each procedure, equilibrium IOP was measured following tight closure with two four-throw adjustable 10-0 nylon sutures. RESULTS: Five scleral flaps were thin or poorly constructed; four of these were in the initial seven procedures, implying learning effect. These had a mean absolute IOP of 7.6 mmHg (range 2.7-12.4 mmHg) and mean relative IOP of 28.3% of baseline (range 10-45.8%) after closure. In the remaining 16 good quality procedures, mean IOP was 1.3 mmHg (range 0-3.4 mmHg) after sclerostomy, confirming minimal outflow resistance before closure. Following flap closure mean IOP was 20 mmHg (SD 4.4, range 15.5-29.3 mmHg) for large (n=8), and 18.7 mmHg (SD 3.6, 15.9-25.8 mmHg) for small (n=8) flaps (unpaired t-test, P=0.26). Mean IOP (% baseline) was 71.6% (SD 8.4, range 60.6-86.6%) and 66% (SD=12.7, 46.8-86.6%) for large and small flap groups, respectively (unpaired t-test, P=0.2). CONCLUSIONS: Well-constructed scleral flaps of both sizes were able to support an average IOP at least two-thirds of baseline, and both had similar absolute IOP levels. Errors in flap construction resulted in loss of IOP control. Smaller flap size does not appear to compromise control of early postoperative IOP using adjustable sutures.

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