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Estimation of noncompartmental parameters: a technical note.

A Dunne·P King
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Abstract

Noncompartmental pharmacokinetic parameters are usually expressed in terms of the area under the so-called first moment curve and the area under the plasma concentration-time curve. These areas are normally computed by numerical integration. There is an inconsistency in the way in which they are presently estimated. This inconsistency is detailed and a consistent approach to the computation of noncompartmental parameters is outlined. The difference between the two methods is illustrated using some data from the literature.

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Models, BiologicalPharmaceutical PreparationsPharmacokineticsJournal ArticleResearch Support, Non-U.S. Gov't

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A Dunne, P King. 1989. Estimation of noncompartmental parameters: a technical note.. https://doi.org/10.1007/bf01059092

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