PubMed · 2743646
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M Potts. 1989. World population problems: an overview.. https://doi.org/10.1097/00003081-198906000-00018
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We evaluated the possible genetic contribution to hyperinsulinism in a series of patients seen during the past 15 years. Of 26 families, 5 (19%) had more than one child affected (multiplex family). There were no apparent differences between patients in the 5 multiplex and 21 simplex families, clinically, biochemically, or on histologic examination of the pancreatic specimens. The families studied had a total of 63 offspring; the 26 index patients had 37 siblings, 6 of whom were affected. After four patients with hyperinsulinism caused by adenoma were excluded from the study, segregation analysis was carried out to test the data for agreement with results expected if familial and isolated hyperinsulinism represented a single disease with recessive mode of inheritance and a segregation ratio of 0.25. Excellent agreement was found between the observed number of affected siblings (20) and the expected number (19.65), with a segregation ratio of 0.254. The results were consistent with the hypothesis that in most or all cases, hyperinsulinism is inherited as an autosomal recessive disease. There was no evidence of distinct familial and sporadic types.
A questionnaire to evaluate the epidemiology of household medications was verbally administered to 498 households in urban Gweru and Harare. Self-medication was common in 95pc of the households. The average number of drugs per household was four. The commonest items encountered were analgesics, cough, cold and sore throat preparations, dermatologicals, gastrointestinals and antimalarials. The majority of the respondents usually chose an appropriate drug for a particular symptom. The sources of the medications found in the households were chemist/pharmacy, shop/supermarket, hospital/clinic, friends and relatives.