PubMed · 276717
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P G Fama. 1978-05-24. Depression after 50.. https://pubmed.ncbi.nlm.nih.gov/276717/
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Patients with spinal cord injury (SCI) may develop depression. This may be related to adjustment to living with an SCI in addition to dealing with complications of the injury, such as spasticity. Pharmacologic treatment of depression can be difficult because of neurochemical and receptor changes that are associated with SCI. Newer antidepressant agents are purported to have selective activity by alteration of serotonergic neurotransmission. A case report is presented that illustrates exacerbation of spasticity by this family of antidepressant medications. Mechanisms possibly explaining this exacerbation of spasticity are the effects of serotonin on motor neuron and reflex activity, denervation supersensitivity, and the serotonin syndrome. Understanding the relationship between serotonergic systems and spasticity can be important in treating depression in patients with spasticity.
The Beck Depression Inventory-II (BDI-II) [Beck, A. T., Steer, R. A. & Brown, G. K. (1996). Manual for Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation.] and Anxiety Inventory (BAI) [Beck, A. T. & Steer, R. A. (1993a). Manual for the Beck Anxiety Inventory. San Antonio, TX: Psychological Corporation.] were administered to 840 outpatients who were diagnosed with various types of psychiatric disorders to determine whether the general symptom compositions and relative amounts of variance of the common and specific dimensions of self-reported anxiety and depression for these instruments would be comparable to those that had been found by Steer et al. [Steer, R. A., Clark, D. A., Beck, A. T. & Ranieri, W. F. (1995). Common and specific dimensions of self-reported anxiety and depression: A replication. Journal of Abnormal Psychology, 104, 542-545.] with the BAI and amended Beck Depression Inventory (BDI-IA) [Beck, A. T. & Steer, R. A. (1993b). Manual for the Beck Depression Inventory. San Antonio, TX: Psychological Corporation.]. A Schmid-Leiman transformation was used with the iterated-principal-factor pattern matrix of the BAI and the BDI-II loadings and indicated that the overall symptom compositions and relative amounts of variance that were explained by the one common and two specific anxiety and depression dimensions were comparable to those previously found with the BDI-IA.
To examine the effects of quantity of nonmaternal care across the first 3 and 5 years of life on problem behavior and affective-cognitive indices of adjustment, and to test the hypotheses that parenting mediates effects of nonmaternal care, 120 working- and middle-class, two-parent Caucasian families rearing firstborn sons were studied. More time in nonmaternal care across the first 3 and 5 years predicted more mother-reported externalizing problems when children were ages 3 and 5 (and somewhat more father-reported externalizing problems at age 5), as well as more negative mothering and less positive fathering during the toddler years. Effects of nonmaternal care on externalizing problems became insignificant once observed parenting was controlled, thereby providing evidence of the mediational effects of parenting. More time in nonmaternal care across the first 5 years predicted more negative adjustment on a composite lab-based measure of affective-cognitive functioning at age 5 (e.g., attributional bias, social problem solving, preference for negative story plots), and this effect was only modestly attenuated upon controlling for parenting. Results are discussed in terms of related research and the current context of child care in America.