The interaction between oxygen and vascular wall.

J Grote; G Siegel; K Zimmer; A Adler

doi:10.1007/978-1-4684-5643-1_64

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The interaction between oxygen and vascular wall.

J Grote·G Siegel·K Zimmer·A Adler

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Abstract

In vascular strips of canine carotid arteries stepwise lowering of oxygen tension from hyperoxic levels of 550 mmHg to 20 mmHg caused in preparations with endothelium a dose-dependent hyperpolarization and relaxation of smooth muscle cells when oxygen tensions between approximately 150 mmHg and 35 mmHg were attained. Pronounced hypoxia with oxygen tensions below 30 mmHg induced a depolarisation and an increase in force generation. During comparable investigations on vessel preparations without endothelium only a slight hyperpolarization and relaxation of the smooth muscle were observed when decreasing the oxygen tension from 550 mmHg to approx. 35 mmHg. In the presence of indomethacin (10(-5) M) a small but significant reduction in the hypoxia-induced hyperpolarization and decrease in smooth muscle tone was found in intact vascular strips with endothelium. Depolarisation and contraction occurred at oxygen tensions below approx. 50-60 mmHg.

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Animals Carotid Arteries Dogs Endothelium, Vascular In Vitro Techniques Membrane Potentials Muscle, Smooth, Vascular Oxygen Partial Pressure Journal Article

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J Grote, G Siegel, K Zimmer, A Adler. 1989. The interaction between oxygen and vascular wall.. https://doi.org/10.1007/978-1-4684-5643-1_64

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