Solid tumors and enzyme activity in human lymphocytes.

R Giacchi; M Sebastiani; F Canestrari; M Di Quirico; F Lungarotti

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PubMed · 2834304

Solid tumors and enzyme activity in human lymphocytes.

R Giacchi·M Sebastiani·F Canestrari·M Di Quirico·F Lungarotti

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Abstract

A study on the enzyme activity of glucose metabolism in the lymphocytes of patients with solid malignant tumors is reported. The results have shown a 30% mean increase of the hexokinase (HK) activity in patients with solid malignant tumors as compared to the mean value observed in a group of healthy subjects. A relationship between level of HK increase and stage of tumor was also observed. The other examined enzyme activities, phosphofructokinase (PFK), pyruvate-kinase (PK), phosphoglycerate-kinase (PGK), phosphoglucoisomerase (PGI), glyceraldehyde-phosphate dehydrogenase (GAPD) glucose-6-phosphate dehydrogenase (G-6PD), 6-phosphogluconate dehydrogenase (6-PGD) and enolase did not show significant changes. It is concluded that even though the use of HK as tumor marker cannot be hypothesized at the present time, a significant relation between an increased activity of this enzyme and presence of the tumor is unquestionable. Therefore, this biochemical effect induced away from the neoplastic tissue deserves further study.

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Adenocarcinoma Adult Aged Carbohydrate Dehydrogenases Carcinoma, Squamous Cell Digestive System Neoplasms Female Glucose-6-Phosphate Isomerase Glyceraldehyde-3-Phosphate Dehydrogenases Humans Lung Neoplasms Lymphocytes Male Middle Aged Phosphopyruvate Hydratase Phosphotransferases Journal Article

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R Giacchi, M Sebastiani, F Canestrari, M Di Quirico, F Lungarotti. 1987. Solid tumors and enzyme activity in human lymphocytes.. https://pubmed.ncbi.nlm.nih.gov/2834304/

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