[Effect of a decrease in perfusion pressure on the alpha-adrenergic reactions of the coronary vessels].

E B Novikova; L I Serebriakova; O V Tskitishvili

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PubMed · 2848968

[Effect of a decrease in perfusion pressure on the alpha-adrenergic reactions of the coronary vessels].

E B Novikova·L I Serebriakova·O V Tskitishvili

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Abstract

Acute dog experiments involving the perfusion of donor coronary arteries demonstrated that alpha-adrenoreceptor stimulation in the presence of a beta-adrenergic block resulted in a 30% drop of coronary flow. This response is maintained at low perfusion coronary blood pressure values (up to 25 +/- 13 mmHg, p less than 0.02), whereas coronary dilatation reserve is already fully depleted at 60 +/- 8 mmHg, suggesting that the degree of coronary arterial stenosis associated with coronary insufficiency may be a decisive factor shaping coronary response to alpha-adrenoreceptor stimulation.

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Animals Blood Pressure Coronary Circulation Coronary Vessels Dogs Female Hyperemia Isoproterenol Male Norepinephrine Perfusion Propranolol Receptors, Adrenergic, alpha Vascular Resistance English Abstract Journal Article

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E B Novikova, L I Serebriakova, O V Tskitishvili. 1988. [Effect of a decrease in perfusion pressure on the alpha-adrenergic reactions of the coronary vessels].. https://pubmed.ncbi.nlm.nih.gov/2848968/

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