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Amiodarone does not affect digoxin kinetics in the rabbit.

D C Buss·P A Routledge
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Abstract

It has been reported that amiodarone may interact with digoxin in man. We investigated the effects of amiodarone pretreatment (35 mg kg-1 day-1) on the pharmacokinetics of a single dose of digoxin (50 micrograms kg-1) in 6 rabbits. Total body clearance of digoxin was 138.84 +/- 44.67 and 147.99 +/- 29.17 ml min-1, serum half life 187.9 +/- 60.9 and 181.34 +/- 25.57 min and volume of distribution 35.4 +/- 8.54 and 37.8 +/- 3.9 litres before and after amiodarone treatment, respectively. None of these changes were statistically significant. We conclude that the presence of an amiodarone-induced change in digoxin pharmacokinetics in the rabbit was not evident and that other animal models will be necessary for studying this interaction.

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AmiodaroneAnimalsBenzofuransDigoxinDrug InteractionsHalf-LifeKineticsRabbitsJournal Article

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D C Buss, P A Routledge. 1985. Amiodarone does not affect digoxin kinetics in the rabbit.. https://doi.org/10.1111/j.2042-7158.1985.tb05111.x

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