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LY141865: a relatively selective DA2 agonist with complex ocular activity.

D E Potter·J A Burke
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Abstract

LY141865 (LY), an ergoline derivative, was investigated for ocular effects in rabbits and monkeys. LY lowered intraocular pressure (IOP) bilaterally in monkeys and rabbits, prevented the bilateral rise in IOP caused by oral waterloading in rabbits and slowed the rate of IOP recovery bilaterally in rabbits. The ocular hypotensive activity of LY in rabbits was inhibited by sympathectomy and pretreatment with sulpiride. Since LY has cardiovascular effects that are centrally mediated, ocular responses may also be mediated, in part, by an action in the CNS.

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AnimalsCebusDopamine AgentsErgolinesEyeIntraocular PressureMaleMydriaticsOcular HypertensionPupilQuinpiroleRabbitsSulpirideSympathectomy, ChemicalJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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D E Potter, J A Burke. 1988. LY141865: a relatively selective DA2 agonist with complex ocular activity.. https://doi.org/10.1089/jop.1988.4.19

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