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PubMed · 2914431

Patch testing with nickel chloride in a hydrogel.

A Fullerton·T Menné·A Hoelgaard
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Abstract

Various concentrations of NiCl2 in a hydrogel were evaluated as a possible alternative to the standard patch test material of 5% NiSO4 pet. Patch test responses were recorded on a total of 430 patients with known or suspected contact allergy. A NiCl2 concentration of 1% or less in the hydrogel failed to elicit a response in some patients who reacted to 5% NiSO4 pet. The 2% NiCl2 hydrogel produced a small increase in response frequency and may reduce false-negative reactions. Along with the ability of the material to improve the topical bioavailability of nickel ions, more irritant reactions were observed. However, in cases with a positive history and a negative patch test with petrolatum, the hydrogel prepared from Methocel-E-4M seems to be a useful alternative vehicle for water-soluble allergens.

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Dermatitis, ContactGelsHumansNickelPatch TestsPetrolatumPharmaceutical VehiclesSkin TestsComparative StudyJournal Article

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BibTeXRIS

A Fullerton, T Menné, A Hoelgaard. 1989. Patch testing with nickel chloride in a hydrogel.. https://doi.org/10.1111/j.1600-0536.1989.tb03089.x

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