PubMed · 2930243
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D B Walsh. 1989. Sweat tests and flucloxacillin.. https://doi.org/10.1136/adc.64.2.308
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Penicillin sulfones, which structurally incorporate both a 6-position alkylidene substituent and a 2'beta substituent, have been synthesized and evaluated as inhibitors of class C and class A serine beta-lactamases. Incorporation of the 2'beta-substituent generally improves inhibitory activity. Substituents that improve transport across the bacterial cell membrane have also been incorporated.