Ir gene influence on DNP-specific B-memory-cell formation.

S Y Sokol; T K Borisova

doi:10.1016/0008-8749(87)90138-9

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Ir gene influence on DNP-specific B-memory-cell formation.

S Y Sokol·T K Borisova

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Abstract

It is well known that Ir genes control the antibody production. To investigate whether they also influence B-memory-cell generation, CBA mice (nonresponders) were primed with dinitrophenyl-poly-(L-tyr,L-glu)-poly-(D,L-ala)-poly-(L-lys)-DNP-TGAL conjugate. At the same time animals were injected with ovalbumin (OVA) to activate OVA-specific T helpers. Two to four weeks later animals were challenged with DNP-OVA conjugate and the number of IgG-producing B cells was determined. The data presented indicate that carrier-specific MHC-restricted T helpers are not required for B-memory-cell generation. It is concluded that the defect of IgG response to DNP-TGAL in CBA mice is caused by a block in the maturation of memory cells to antibody-producing cells.

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Animals Antibody-Producing Cells Dinitrobenzenes Genes, MHC Class II Immunologic Memory Lymphocyte Activation Lymphocyte Cooperation Major Histocompatibility Complex Mice Mice, Inbred C57BL Mice, Inbred CBA Nitrobenzenes Ovalbumin Peptides T-Lymphocytes, Helper-Inducer Journal Article

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S Y Sokol, T K Borisova. 1987. Ir gene influence on DNP-specific B-memory-cell formation.. https://doi.org/10.1016/0008-8749(87)90138-9

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