Cyclohexyladenosine binding in rat striatum.

H G Lloyd; T W Stone

doi:10.1016/0006-8993(85)90238-0

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Cyclohexyladenosine binding in rat striatum.

H G Lloyd·T W Stone

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Abstract

N6-Cyclohexyl-[3H]adenosine [( 3H]CHA) binds specifically to rat brain membranes prepared from the caudate-putamen complex with a Kd value of 2.50 +/- 0.39 nM and Bmax of 458 +/- 51 fmol/mg protein. Lesioning the nigrostriatal dopaminergic pathway using 6-hydroxydopamine failed to alter [3H]CHA binding characteristics. Intrastriatal kainate lesions reduced the binding capacity of [3H]CHA by 28% though this was not statistically significant (0.1 less than P greater than 0.05). In kainate-lesioned striata, however, 2-deoxyglucose uptake was reduced by only 39%.

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Adenosine Animals Caudate Nucleus Corpus Striatum Hydroxydopamines Kainic Acid Male Oxidopamine Putamen Rats Rats, Inbred Strains Receptors, Cell Surface Receptors, Purinergic Journal Article Research Support, Non-U.S. Gov't

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H G Lloyd, T W Stone. 1985-05-20. Cyclohexyladenosine binding in rat striatum.. https://doi.org/10.1016/0006-8993(85)90238-0

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