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PubMed · 3003678

Should nucleotide sequence analyzing computer algorithms always extend homologies by extending homologies?

L Burnett·A Basten·W J Hensley
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Abstract

Most computer algorithms used for comparing or aligning nucleotide sequences rely on the premise that the best way to extend a homology between the two sequences is to select a match rather than a mismatch. We have tested this assumption and found that it is not always valid.

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L Burnett, A Basten, W J Hensley. 1986-01-10. Should nucleotide sequence analyzing computer algorithms always extend homologies by extending homologies?. https://doi.org/10.1093/nar%2F14.1.425

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