PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 3052736

Valve surgery in children.

W G Williams
View original source ↗Export metadata ↓

Abstract

Valve surgery constitutes a small percentage of overall pediatric cardiac practice. Most of the lesions seen are congenital anomalies, often in association with other lesions. Valvotomy and valvuloplasty can usually provide good long term palliation, although reoperation is probably inevitable. The late results of valve replacement in children have been compromised by the rapid calcification of biologic valves. There is some evidence to suggest that this may not occur with homograft valves. The importance of implanting as large a valve as possible is emphasized and follow-up must include an assessment of whether the child is outgrowing the previously implanted prosthesis.

Explore related subjects

Aortic ValveBioprosthesisCanadaChildCosts and Cost AnalysisHeart Valve DiseasesHeart Valve ProsthesisHumansMitral ValveJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

W G Williams. 1988. Valve surgery in children.. https://pubmed.ncbi.nlm.nih.gov/3052736/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2008

Right-sided vegetation unmasks aortic endocarditis.

Echocardiography is a key tool in the diagnosis of infective endocarditis. Although transthoracic echocardiography is the first step in the work-up, transoesophageal echocardiography is mandatory for the evaluation of the exact extent of the infectious process. Indeed, perivalvular abscess can fistulate towards different heart chambers, leading sometimes to critical clinical situations.

Aortic Valve↗
PubMed2007

Aortic translocation for the management of transposition of the great arteries with a ventricular septal defect, pulmonary stenosis, and hypoplasia of the right ventricle.

A 2-month-old patient with transposition of the great arteries, a ventricular septal defect, pulmonary stenosis, and severe hypoplasia of the right ventricle successfully underwent a biventricular repair utilizing the aortic translocation technique. Advantages of this surgical repair over the Rastelli procedure in the management of this complex congenital heart lesion are discussed.

Aortic Valve↗
PubMed2007

Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformations.

The aim of this study was to identify regions of the genome that harbor genes influencing inheritance of bicuspid aortic valve (BAV) and/or associated cardiovascular malformation (CVM). Aortic valve disease is an important clinical problem, which often results in valve replacement, the second most common cardiac surgery in the United States. In every age group, a majority of cases of valve disease involves a BAV. BAV is the most common CVM with a reported prevalence of 1-2%. Heritability studies indicate that BAV determination is almost entirely genetic. We used a family-based genome-wide linkage analysis with microsatellite markers. Parametric and nonparametric analyses were performed with the software GENEHUNTER and SOLAR (Sequential Oligogenic Linkage Analysis Routines). Thirty-eight families (353 subjects) with BAV and/or associated CVM were assessed. Each participant underwent a standardized echocardiographic examination. The highest LOD score, 3.8, occurred on chromosome 18q between markers D18S68 and D18S1161. Two other chromosomal regions, 5q15-21 (between D5S644 and D5S2027) and 13q33-qter (between D13S1265 and 13qter), exhibited suggestive evidence of linkage (LOD > 2.0). Further, two previously reported linkage peaks on 9q34 and 17q24 were replicated in family specific analyses. No significant X chromosome linkage peaks were identified. In this genome-wide scan we demonstrate for the first time, that BAV and/or associated CVM exhibit linkage to chromosomes 18q, 5q and 13q. These regions likely contain genes whose mutation results in BAV and/or associated CVM indicating their important role in valvulogenesis and cardiac development.

Aortic Valve↗