[T-lymphocytes and their function in Hodgkin's disease].

G Michlmayr

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PubMed · 308921

[T-lymphocytes and their function in Hodgkin's disease].

G Michlmayr

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Abstract

In untreated patients with Hodgkin's disease the percentage of T-lymphocytes was significantly reduced in comparison to healthy controls independent of the stage of the disease. The absolute number of T-lymphocytes was also reduced in most patients. The response of lymphocytes after PHA-stimulation was diminished parallel with the skin reactivity: Normal results were obtained in early stages and with favorable histological types whilst low values were found in stages III and IV and in unfavourable histological types. A correlation between the percentage of T-lymphocytes and the PHA-stimulation was found in early stages, but not in stages III and IV. There was also a correlation between the absolute number of T-lymphocytes and skin reactivity. The percentage of DNA-synthesizing lymphocytes was significantly higher than in normal blood. The highest values were found in stages III and IV and in unfavourable histological types. After radiation therapy the T-lymphopenia, the diminished PHA-stimulation as well as anergy was more pronounced than after chemotherapy.

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Antineoplastic Agents Cell Count DNA, Neoplasm Hodgkin Disease Humans Lymphocytes Phytohemagglutinins Stimulation, Chemical T-Lymphocytes English Abstract Journal Article

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G Michlmayr. 1978-10-12. [T-lymphocytes and their function in Hodgkin's disease].. https://pubmed.ncbi.nlm.nih.gov/308921/

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