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Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats.

G Suárez·R Rajaram·K C Bhuyan·A L Oronsky·J A Goidl
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Abstract

As a consequence of an increased flux through the sorbitol pathway fructose levels rise in various tissues in diabetes. Also, in vitro nonenzymatic fructosylation of protein induces the generation of fluorescence at a rate 10 times greater than glucosylation. The administration of sorbinil, an aldose reductase inhibitor known to lower tissue fructose concentration, to experimental diabetic rats led to a decrease in the fluorescence related to advanced Maillard products in their skin collagen. This effect is consistent with the in vivo occurrence of nonenzymatic fructosylation of collagen. A potential pathogenetic role for this posttranslational modification in diabetic complications should be considered.

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Aldehyde ReductaseAnimalsBlood GlucoseCollagenDiabetes Mellitus, ExperimentalGlycosylationImidazolesImidazolidinesMaleRatsRats, Inbred StrainsSkinSolubilitySpectrometry, FluorescenceSugar Alcohol DehydrogenasesJournal ArticleResearch Support, Non-U.S. Gov't

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G Suárez, R Rajaram, K C Bhuyan, A L Oronsky, J A Goidl. 1988. Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats.. https://doi.org/10.1172/jci113641

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