Cholinergic urticaria, passive transfer experiments from human to monkey.

G M Murphy; M W Greaves; P E Zollman; R K Winkelmann

doi:10.1159/000248603

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Cholinergic urticaria, passive transfer experiments from human to monkey.

G M Murphy·M W Greaves·P E Zollman·R K Winkelmann

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Abstract

Passive transfer experiments in cholinergic urticaria were carried out from 16 patients to a Macaca cymnologous monkey. Intravenous Evans blue dye was used to demonstrate vascular permeability. The animal was challenged after 24 h first by heating the serum-injected dorsal skin to 45 degrees C and secondly by superinjection of acetylcholine into serum-injected sites, and a control site. Local heat proved insufficient to evoke a response. Seven of 16 serum-injected sites showed positive reaction to acetylcholine, control injection of acetylcholine did not. These experiments suggest the presence of a serum factor in cholinergic urticaria which, with acetylcholine, causes increased vascular permeability.

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Acetylcholine Adolescent Adult Animals Cholinergic Fibers Female Haplorhini Humans Immunization, Passive Injections, Intradermal Intradermal Tests Male Middle Aged Urticaria Journal Article Research Support, Non-U.S. Gov't

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G M Murphy, M W Greaves, P E Zollman, R K Winkelmann. 1988. Cholinergic urticaria, passive transfer experiments from human to monkey.. https://doi.org/10.1159/000248603

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