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PubMed · 3148484

Eicosanoids and skin.

G De Nucci
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Abstract

A better understanding of the physiological and pathological roles of lipoxygenase metabolites on skin will be obtained with the development of safe and specific 5- and 12-lipoxygenase inhibitors. Lipocortins have been cloned and the results of clinical trials with them should provide further insight into the mechanism(s) of action of steroids on skin diseases.

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Eicosanoic AcidsHumansLipoxygenaseProstaglandin-Endoperoxide SynthasesSkinSkin DiseasesSkin Physiological PhenomenaJournal ArticleReview

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BibTeXRIS

G De Nucci. 1988. Eicosanoids and skin.. https://doi.org/10.1042/bst0160680

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Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds.

The fatty acid compositions of half-seeds and whole seeds of the temperature-dependent high-stearic-acid sunflower (Helianthus annuus L.) mutant CAS-14 were unexpectedly different. We found that there is a longitudinal gradient starting from the embryo up to the end of the cotyledon. The stearic acid content varied from 9.7 to 34.6% in seeds produced in a growth chamber (39/24 degrees C; day/night), and from 14.0 to 34.4% in seeds produced in the field during the summer season (35-40 degrees C in daylight and 20-25 degrees C at night). The gradient occurs throughout seed formation, and is due to a spatial and non-temporal regulation of stearic acid desaturation. A similar temperature-regulated behaviour, but for oleic and linoleic acid contents, was found in normal sunflower seeds. Since the deposition of oil bodies was homogeneous during seed formation, seeds showed the gradient throughout their development. This non-homogeneous distribution must be due to differences in the enzymatic pathway of de-novo fatty acid desaturation along the seed, resembling a morphogen gradient. Other high-stearic-acid mutant lines, such as CAS-3, did not show any gradient. This is the first time that a gradient and an inheritable maternal control of the fatty acid composition have been found in oilseeds.

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