T-cell function in B-lymphocyte-deprived mice.

J Gordon; F Paraskevas; S T Lee

doi:10.1016/0008-8749(85)90088-7

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T-cell function in B-lymphocyte-deprived mice.

J Gordon·F Paraskevas·S T Lee

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Abstract

Previous work has identified selective defect(s) in T cells in mice deprived of B lymphocytes by the chronic administration of anti-IgM antibody. Experiments described in the present communication revealed that anti-IgM-treated mice do not possess T cells with surface Ia and FcR, and, unlike T cells from normal animals, they also fail to bind these molecules in vitro. Functional assays disclosed that an anti-suppressor pathway which relies on Ia+ donor and acceptor T cells is interrupted in these mice at both levels. These observations may provide an insight to explain the selective failure of some T cells when B lymphocytes have been deleted.

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Animals Antibodies, Anti-Idiotypic Antibody Formation B-Lymphocytes Histocompatibility Antigens Class II Immunoglobulin M Lymphocyte Cooperation Lymphokines Mice Mice, Inbred Strains Prostatic Secretory Proteins Receptors, Fc T-Lymphocytes T-Lymphocytes, Regulatory Thymus Gland Journal Article Research Support, Non-U.S. Gov't

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J Gordon, F Paraskevas, S T Lee. 1985. T-cell function in B-lymphocyte-deprived mice.. https://doi.org/10.1016/0008-8749(85)90088-7

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