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Necrotizing tracheobronchitis. An ischemic lesion.

J B Hanson·G Waldstein·J A Hernandez·L L Fan
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Abstract

Neonates with necrotizing tracheobronchitis present a diverse clinical spectrum from asymptomatic disease to severe airway obstruction. A retrospective clinicopathologic study of 206 neonatal autopsy reports spanning a three-year period yielded 122 cases of necrotizing tracheobronchitis with an incidence of 59%. All study patients received treatment prior to the development of high-frequency ventilator jet, oscillator, or interruption. The site and submucosal depth of airway involvement was variable. The most commonly affected anatomic site was the middle or thoracic trachea (56%). The common cause identified was severe ischemia to the airway mucosa and submucosa, occurring with profound birth asphyxia and/or shock. The presence of ischemia supports the concept that decreased tracheoperfusion may be an important factor in the development of tracheobronchial abnormalities.

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Apgar ScoreBronchiBronchitisHumansInfant, NewbornIschemiaNecrosisRespiration, ArtificialTracheaTracheitisJournal Article

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BibTeXRIS

J B Hanson, G Waldstein, J A Hernandez, L L Fan. 1988. Necrotizing tracheobronchitis. An ischemic lesion.. https://doi.org/10.1001/archpedi.1988.02150100088034

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