A rat model for pneumococcal otitis media.

A Hermansson; P Emgård; K Prellner; S Hellström

doi:10.1016/s0196-0709(88)80013-9

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A rat model for pneumococcal otitis media.

A Hermansson·P Emgård·K Prellner·S Hellström

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Abstract

The middle ears of 29 male Sprague-Dawley rats were injected with viable pneumococci, type 3 or 6A, and changes were monitored by otomicroscopy and analysis of bacterial samples from middle ear effusions, blood, and the nasopharynx. Depending on the type of pneumococci and its concentration, three responses were noted: otitis media with purulent effusion, otitis media with serous effusion, or no reaction. The mortality rate was low and the animals recovered without permanent deterioration or otomicroscopically discernable change. The results of this study show the rat to be a suitable animal model for the study of bacterial otitis media.

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Animals Disease Models, Animal Male Otitis Media with Effusion Pneumococcal Infections Rats Rats, Inbred Strains Journal Article Research Support, Non-U.S. Gov't

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A Hermansson, P Emgård, K Prellner, S Hellström. A rat model for pneumococcal otitis media.. https://doi.org/10.1016/s0196-0709(88)80013-9

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