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PubMed · 3178480

Recombinant human tumor necrosis factor increases granulocyte cell-surface complement receptor number.

D Reed·F D Moore
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Abstract

Exposure of human buffy-coat granulocytes to tumor necrosis factor (TNF) produced cellular activation as indicated by an increase in the neutrophil and monocyte cell-surface number of C3b receptors (measured by indirect immunofluorescence). The degree of receptor increase depended on the dose of TNF from 25 to 1250 pg/mL. Results of kinetic analysis confirmed this response: TNF, 250 pg/mL, caused an increase in the C3b receptor number within ten minutes. Purified neutrophils exhibited a similar increase in cell-surface C3b receptors dependent on the concentration of TNF. Tumor necrosis factor could be a mediator of granulocyte activation in patients.

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GranulocytesHumansMembrane ProteinsMonocytesNeutrophilsReceptors, ComplementRecombinant ProteinsTumor Necrosis Factor-alphaJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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D Reed, F D Moore. 1988. Recombinant human tumor necrosis factor increases granulocyte cell-surface complement receptor number.. https://doi.org/10.1001/archsurg.1988.01400350047006

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