Developmental changes of caffeine elimination in infancy.

G Pons; O Carrier; M O Richard; E Rey; P d'Athis; C Moran; J Badoual; G Olive

doi:10.1159/000457700

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Developmental changes of caffeine elimination in infancy.

G Pons·O Carrier·M O Richard·E Rey·P d'Athis·C Moran·J Badoual·G Olive

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Abstract

Five neonates (4 premature) and 16 infants (6 prematurely born), 15-588 days old, received caffeine as citrate salt for apnea. Plasma samples were collected 0, 2, 4, 6 h after a dose and before the next scheduled one. Patients 8 and 9 were serially studied. Caffeine plasma concentrations were determined using HPLC. The caffeine elimination half-life and clearance varied linearly with gestational age and exponentially with postnatal age, the plateau being reached during the second trimester of life. Dose regimen guidelines as a function of postnatal age were derived from individually calculated doses and dosing intervals in order to achieve, at steady state, a caffeine mean plasma concentration of 11 mg/l with a minimum of 7.5 mg/l and a maximum of 14.5 mg/l. We suggest dosing intervals for infants before 1 month, 1-2 months, 2-4 months and after 4 months to be equal to 24, 12, 8 and 6 h, respectively. The individual recommended dose varies from 2 to 10 mg/kg (as caffeine base) making caffeine monitoring mandatory in infants.

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Aging Apnea Caffeine Drug Administration Schedule Gestational Age Half-Life Humans Infant Infant, Newborn Infant, Premature, Diseases Journal Article

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G Pons, O Carrier, M O Richard, E Rey, P d'Athis, C Moran, J Badoual, G Olive. 1988. Developmental changes of caffeine elimination in infancy.. https://doi.org/10.1159/000457700

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