Do serotoninergic drugs decrease energy intake by reducing fat or carbohydrate intake? Effect of d-fenfluramine with supplemented weight-increasing diets.

J E Blundell; A J Hill

doi:10.1016/0091-3057(88)90382-6

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Do serotoninergic drugs decrease energy intake by reducing fat or carbohydrate intake? Effect of d-fenfluramine with supplemented weight-increasing diets.

J E Blundell·A J Hill

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Abstract

The capacity of serotoninergic drugs to selectively suppress carbohydrate (CHO) intake was investigated using a procedure sensitive to drug action. The drug d-fenfluramine was administered chronically to rats whose weight had been increased by exposure to either a fat or CHO-supplemented hyperphagia-inducing diet. The drug exerted a more potent anorexic effect and weight-reducing action in rats given the dietary supplements than in control chow-fed rats. Tolerance to the drug was not apparent even after 40 days of treatment. However, there was no evidence for a selective inhibition of CHO intake, nor was the drug more potent with the CHO-supplemented diet. d-Fenfluramine was equally effective against the hyperphagia and weight gain induced by either fat or CHO supplements.

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Animals Body Weight Diet Dietary Carbohydrates Dietary Fats Drinking Behavior Energy Intake Feeding Behavior Female Fenfluramine Rats Journal Article Research Support, Non-U.S. Gov't

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J E Blundell, A J Hill. 1988. Do serotoninergic drugs decrease energy intake by reducing fat or carbohydrate intake? Effect of d-fenfluramine with supplemented weight-increasing diets.. https://doi.org/10.1016/0091-3057(88)90382-6

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