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PubMed · 3263693

On reference values for tumor markers in prostatic carcinoma.

A Lewenhaupt·P Ekman·P Eneroth·A Kallner
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Abstract

Serum contents of prostatic acid phosphatase, neopterin, osteocalcin, tissue polypeptide antigen and CA-50 were measured before onset of treatment in 83 patients suffering from prostatic carcinoma. In an attempt to identify patients with poor prognosis the data were related to patient survival after 2 years. It was found that the standard cut off values, obtained from the upper limits of normal, healthy subjects, were sensitive but had low specificity. A better relation to prognosis was usually found at a higher discrimination limit. The degree of elevation appears more important than the elevation of the markers as such in indicating a poor prognosis. By systematic adjustment of the discrimination levels, higher specificity can be obtained with little loss of sensitivity.

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Acid PhosphataseAntigens, NeoplasmAntigens, SurfaceAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorBiopterinsCalcium-Binding ProteinsHumansMaleNeopterinOsteocalcinPeptidesProstatic NeoplasmsReference ValuesTissue Polypeptide AntigenVitamin KJournal Article

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A Lewenhaupt, P Ekman, P Eneroth, A Kallner. 1988. On reference values for tumor markers in prostatic carcinoma.. https://pubmed.ncbi.nlm.nih.gov/3263693/

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