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Subacute acetaminophen overdose after incremental dosing.

R D Mathis·J S Walker·D W Kuhns
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Abstract

A case of acetaminophen poisoning following the ingestion of 26 g of acetaminophen by incremental dosing over a 25-h period is reported. At presentation, seven h after the last ingestion, the patient experienced hematemesis, the acetaminophen level was 150 micrograms/mL, and the SGOT was normal. The patient recovered uneventfully following N-acetylcysteine therapy. A review of the pharmacology and toxicity of acetaminophen is discussed. The case illustrates the problems of judging hepatotoxic potential in a multiple-dose acetaminophen ingestion and describes the successful use of N-acetylcysteine in a patient with a "subacute" acetaminophen overdose.

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R D Mathis, J S Walker, D W Kuhns. Subacute acetaminophen overdose after incremental dosing.. https://doi.org/10.1016/0736-4679(88)90249-1

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