Computer-assisted karyotyping with human interaction.

A Oosterlinck; J Van Daele; J De Boer; F Dom; A Reynaerts; H Van Den Berghe

doi:10.1177/25.7.330726

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PubMed · 330726

Computer-assisted karyotyping with human interaction.

A Oosterlinck·J Van Daele·J De Boer·F Dom·A Reynaerts·H Van Den Berghe

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Abstract

A system for machine assisted karyotyping and chromosome analysis has been developed. The system uses a drum- or TV-scanner as input device, runs provisionally in 32 K memory, and also allows human interaction on several stages. The accuracy with which banded chromosomes are karyotyped depends strongly on the type of classifier and varies from 40 up to 80%. The accuracy of the human assisted classifier (98%) comes close to that of a skilled technician (99.5%) using manual chromosomal analysis. Due to technical and memory limitations, the time necessary for the karyotyping of one cell is too long and depends on the interaction time; however karyotyping within 5 min, including human interaction, will be possible in the near future.

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A Oosterlinck, J Van Daele, J De Boer, F Dom, A Reynaerts, H Van Den Berghe. 1977. Computer-assisted karyotyping with human interaction.. https://doi.org/10.1177/25.7.330726

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