Necrotizing lymphadenitis. Electron microscopical and immunohistochemical study.

S Asano; H Kanno; K Tominaga; T Muramatsu; Y Nozawa; Y Akaike; H Segami; H Wakasa

doi:10.1111/j.1440-1827.1987.tb00424.x

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Necrotizing lymphadenitis. Electron microscopical and immunohistochemical study.

S Asano·H Kanno·K Tominaga·T Muramatsu·Y Nozawa·Y Akaike·H Segami·H Wakasa

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Abstract

Seven cases of necrotizing lymphadenitis (NEL) including a pair of male siblings, a female suffering from non-bacterial meningitis, and two cases with the proliferation of monocytes and/or macrophages in the bone marrow are reported. This disease is clinically documented by the occurrence in young adults usually accompanied by painful cervical lymphadenopathy with fever and leukopenia (below 4,000/mm3). Morphological features were characterized by nuclear debris from degenerated lymphocytes and the appearance of blastoid cells and/or immunoblasts and macrophages. Ultrastructurally, tubular inclusions with a close relation to the endoplasmic reticulum were observed in various kinds of cells in the lesion. Immunohistochemical studies revealed that the ratio of helper/suppressor T-lymphocytes became low at the active stage and returned to normal range at the recovery stage. By immuno-histochemical study it was confirmed that suppressor cells mainly corresponded to large transformed lymphocytes and/or immunoblasts and helper cells were degenerated by an unknown agent. Though the pathogenesis of NEL is still uncertain, it is suggested that T-lymphocytes are mainly involved during the course of the disease and lymphocytes show cellular debris or blastoid transformation.

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Adolescent Adult Female Humans Immunoenzyme Techniques Lymphadenitis Male Microscopy, Electron T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't

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S Asano, H Kanno, K Tominaga, T Muramatsu, Y Nozawa, Y Akaike, H Segami, H Wakasa. 1987. Necrotizing lymphadenitis. Electron microscopical and immunohistochemical study.. https://doi.org/10.1111/j.1440-1827.1987.tb00424.x

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