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PubMed · 3357338

Oestriol binding to plasma proteins.

V Moutsatsou·R E Oakey
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Abstract

Simple diffusion experiments indicated that oestriol was retained by human pregnancy plasma more effectively than by albumin solutions of a corresponding concentration. Oestriol bound (Ka = 6 X 10(6) l/mol at 4 degrees C) to a glycoprotein which had been isolated from plasma by adsorption to Concanavalin A. The free energy of binding at 37 degrees C was -38 kJ/mol. Competition experiments indicated that the oestriol binding glycoprotein had properties expected of sex hormone binding globulin. The distribution of oestriol among the protein fractions of human pregnancy plasma--glycoprotein bound 7.8%, albumin bound 78.6%, unbound 13.6%--suggests that this glycoprotein plays little part in the transport of oestriol.

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Binding, CompetitiveBlood ProteinsEstradiolEstriolFemaleGlycoproteinsHumansPregnancyProtein BindingSerum AlbuminThermodynamicsComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

V Moutsatsou, R E Oakey. 1988. Oestriol binding to plasma proteins.. https://doi.org/10.1016/0022-4731(88)90033-7

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