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PubMed · 3376924

Busulfan-induced hepatitis.

L E Morris·T H Guthrie
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Abstract

A 61-yr-old man with chronic myelocytic leukemia treated continuously for 8 yr with busulfan presented with fever, abdominal pain, and elevated liver enzymes in a cholestatic pattern. Evaluation of his liver and biliary tract with ultrasound and computerized tomography disclosed no structural abnormality. A percutaneous needle liver biopsy revealed cellular cholestasis with focal liver cell necrosis accompanied by a mild inflammatory infiltrate. Busulfan was discontinued, with subsequent normalization of liver enzymes and resolution of fever. These findings are interpreted as being compatible with busulfan-induced hepatitis.

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BusulfanChemical and Drug Induced Liver InjuryHumansMaleMiddle AgedCase ReportsJournal Article

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L E Morris, T H Guthrie. 1988. Busulfan-induced hepatitis.. https://pubmed.ncbi.nlm.nih.gov/3376924/

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