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PubMed · 3400640

A genetical model for vitiligo.

P P Majumder·S K Das·C C Li
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Abstract

A genetical model is found to provide a good fit to family data on vitiligo. The model postulates that recessive alleles at a set of four unlinked diallelic loci are involved in the causation of the disorder. Under this multiple recessive homozygosis model, for normal X affected families ascertained through the affected parent, the expected segregation probability is .063; the estimated value is 0.53, which is not significantly different from the expected value. For normal X normal families ascertained through an affected offspring, the expected segregation probability is .037; the estimated value is .04.

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Age FactorsAllelesGene FrequencyGenes, RecessiveHomozygoteHumansModels, GeneticProbabilityVitiligoJournal ArticleResearch Support, Non-U.S. Gov't

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P P Majumder, S K Das, C C Li. 1988. A genetical model for vitiligo.. https://pubmed.ncbi.nlm.nih.gov/3400640/

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