Elastolysis of normal and partially cross-linked elastin.

K Bostancioglu; R P Mecham; J M Wallach

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PubMed · 3435523

Elastolysis of normal and partially cross-linked elastin.

K Bostancioglu·R P Mecham·J M Wallach

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Abstract

Rate of elastolysis by pancreatic and leukocyte elastases of normal and copper deficient porcine aortic elastins were measured using a conductimetric method. Kinetics obey to Michaelis-Menten model for both substrates and enzymes. KM and Vmax values derived from Lineweaver-Burk plots indicate that, if a near uniformity exists in KM, differences were observed in catalytic rates, kcat increasing approximately 40% for copper deficient elastin elastolysis by leukocyte elastase. This higher susceptibility to proteolysis may have implications for understanding turnover of elastin in tissues.

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Animals Aorta Copper Elastin Kinetics Leukocytes Muscle, Smooth, Vascular Pancreas Pancreatic Elastase Swine Journal Article Research Support, Non-U.S. Gov't

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K Bostancioglu, R P Mecham, J M Wallach. 1987. Elastolysis of normal and partially cross-linked elastin.. https://pubmed.ncbi.nlm.nih.gov/3435523/

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