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Altered renal function in chronically hyperprolactinaemic rats.

H O Garland·A G Lewis·C M Milne
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Abstract

1. Standard renal clearance techniques were used to investigate the effects of chronic hyperprolactinaemia on kidney function in male, female and ovariectomized female rats. 2. All hyperprolactinaemic rats showed a significantly increased glomerular filtration rate (G.F.R.) compared to controls. Values were (microliter min-1) 2738 +/- 146 vs. 2299 +/- 99 for males (P less than 0.05), 2236 +/- 79 vs. 1865 +/- 74 for females (P less than 0.01) and 2200 +/- 76 vs. 1941 +/- 62 for ovariectomized females (P less than 0.05). 3. Hyperprolactinaemic rats in all groups also showed a significant increase in absolute tubular reabsorption of water, sodium and chloride compared to their respective controls. Increases here averaged 19%. 4. There was a significantly greater fractional tubular reabsorption of fluid and solutes in hyperprolactinaemic male rats compared to controls. Values were (%) 92.9 +/- 0.6 vs. 90.3 +/- 0.7 for water, 93.0 +/- 0.4 vs. 91.0 +/- 0.6 for sodium and 89.9 +/- 0.7 vs. 86.5 +/- 0.9 for chloride. In each case P less than 0.05. 5. These results imply an osmoregulatory role for prolactin which is not specific to pregnancy or related female reproductive states.

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AbsorptionAnimalsFemaleGlomerular Filtration RateHyperprolactinemiaKidneyKidney TubulesMaleOvariectomyRatsRats, Inbred StrainsJournal ArticleResearch Support, Non-U.S. Gov't

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H O Garland, A G Lewis, C M Milne. 1987. Altered renal function in chronically hyperprolactinaemic rats.. https://doi.org/10.1113/jphysiol.1987.sp016857

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