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PubMed · 35165

The beta-adrenergic receptor of turkey erythrocyte membranes: conformational modification by beta-adrenergic agonists.

S Bottari·G Vauquelin·O Durieu·C Klutchko·A D Strosberg
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Adrenergic beta-AgonistsAdrenergic beta-AntagonistsAnimalsErythrocyte MembraneErythrocytesEthylmaleimideProtein ConformationReceptors, AdrenergicReceptors, Adrenergic, betaTurkeysJournal Article

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S Bottari, G Vauquelin, O Durieu, C Klutchko, A D Strosberg. 1979-02-28. The beta-adrenergic receptor of turkey erythrocyte membranes: conformational modification by beta-adrenergic agonists.. https://doi.org/10.1016/0006-291x(79)90259-6

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In vitro modulation of CNS beta-receptor number by antidepressants and beta-agonists.

In vitro incubation of rat cerebral cortex slices with antidepressant drugs reduced beta-adrenergic receptor binding of 3H-dihydroalprenolol by 30%. The decrease was maximum after 60 min, and was reversible after 120 min. (-)-Isoproterenol incubation caused a rapid and reversible loss (60%) of beta-receptor binding. Both effects were due to a decrease in beta-receptor sites. In vitro beta-receptor subsensitivity due to desipramine and isoproterenol was non-additive. The observed reversible loss of beta-receptor sites may be an initial phase of the beta-receptor down-regulation by antidepressants seen in vivo.

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